What is serrapeptase good for?
Serrapeptase, also known as serratiopeptidase, is what is known as a proteolytic enzyme, which means that it is able to break down proteins into smaller fragments, which we know as amino acids.
Origins of serrapeptase
Interestingly, serrapeptase is originally formed by the bacteria Serratia marcescens, found in the digestive tract of the Bombyx mori silkworm, the purpose of which is to help the emerging moths dissolve their cocoons. Modern serrapeptase production bypasses the need for silkworm by working directly with the bacteria.
Anti-inflammatory properties
Serrapeptase is known to possess significant anti-inflammatory effects, as well as being able to inhibit the production of pain-inducing compounds that are associated with inflammation.
One review of five studies was able to demonstrate how serrapeptase helps reduce swelling and pain following the surgical removal of wisdom teeth, while another study involving 200 people with inflammatory ear, nose, and throat conditions found that those who took serrapeptase experienced a significant reduction in their symptoms, when compared to the group that took the placebo.
Benefits for cardiovascular health
Also, in a way very similar to how the enzyme nattokinase functions, serrapeptase is able to break down fibrin, a type of protein that forms the structure of blood clots, as well as dead and damaged tissue. It is thought that this action allows serrapeptase to dissolve dangerous plaques and blood clots in your arteries that could otherwise potentially cause a stroke or heart attack.
A review in 2021 also found that serrapeptase showed promising results in the treatment of thrombosis.
Through these same mechanisms, serrapeptase is thought to be a promising treatment for atherosclerosis, a cardiovascular condition characterized by the narrowing and hardening of arteries due to a buildup of plaque in the artery walls.
Wound healing properties
Lastly, due to serrapeptase's ability to reduce inflammation in the skin and break down damaged tissue, it is able to promote wound healing.
When should I take serrapeptase?
Serrapeptase is best taken on an empty stomach, at least half an hour before eating, or alternatively at least two hours since your last meal.
There does not seem to be a consensus on the best time of day for taking serrapeptase, however you might want to consider taking it before going to bed, so that its fibrin-dissolving properties can get to work uninterrupted while you sleep.
What does serrapeptase combine well with?
Serrapeptase with manganese or zinc, for improved efficacy
Serrapeptase has been found to be more stable and demonstrate higher efficacy when it is in the presence of metal ions, such as zinc or manganese.
What should I avoid taking serrapeptase with?
Avoid with blood-thinning medication
Serrapeptase is known for its anticoagulant properties, and could have a blood-thinning effect that may exacerbate the effects of blood-thinning medications, so avoid taking such medications and serrapeptase at the same time.
Serrapeptase data sources & further reading
Last updated by Asklepios on 30th January, 2025